EGFR and non-small cell lung carcinoma: In these patients, monotherapy with first or second generation EGFR-tyrosine kinase inhibitors (EGFR-TKIs) as first-line treatment for EGFR-mutated NSCLC is the standard therapy, and the median progression-free survival (PFS) with this treatment ranges from 9.2-14.7 months5-7.