It has been shown 74 that p300 knockout HCT-116 cells exhibit butyrate resistance (Fig. 3, from 74); consistent with the loss of p300 expression observed in the HCT-R line 52, a butyrate-resistant colorectal cancer cell line derived from HCT-116 cells exposed to increasing levels of butyrate over time 2. Here, EP300 is linked to colorectal cancer.