On the one hand, LT97 cells exhibit slower proliferative dynamics than do colorectal cancer cells 3, suggesting a lesser dependence on apoptotic mechanisms involving cell cycle progression and Rb inactivation; on the other hand, LT97 cells are more sensitive to the effects of the histone deacetylase inhibitor butyrate (proliferation and apoptosis) 4,53, so the overall influence of Wnt-Rb-mTOR on LT97 physiology is unpredictable and must be empirically determined. The gene discussed is RB1; the disease is colorectal cancer.