In the early years, staging of tumors was performed by using the Durie-Salmon staging system.6 In recent years, the International Myeloma Working Group (IMWG) has proposed an international staging system (ISS) for staging multiple myeloma with β2-MG and serum albumin levels.7 It helps to predict the prognosis of the disease. This evidence concerns the gene ALB and plasma cell myeloma.