We compared the expression of EPB41L4A before and after relapse in the same MM patient and compared the expression of EPB41L4A in the same patient after untreated and pre-1st chemotherapy, and found that there was no difference in the expression of EPB41L4A before and after, but we also found that MM patients with relapsed had lower expression levels of EPB41L4A than MM patients with non-relapsed. This evidence concerns the gene EPB41L4A and Miyoshi myopathy.