Overexpression of FGFR3 can lead to proliferation of myeloma cells leading to poor prognosis in MM patients, but it is often used as a therapeutic target to improve MM prognosis.58, 59 Not only is the expression of EPB41L4A highly consistent with “good” or “bad” genes in MM, but EPB41L4A expression is an independent prognostic factor for MM patients (see results). This evidence concerns the gene FGFR3 and Miyoshi myopathy.