Supplementary Figure 1a and b show that CBR1 depletion did not affect proliferation of HNSCC cells at any time point. In the invasion assay, we found that CBR1 inhibition resulted in a two- to three-fold increase of invasive HNSCC cells (SNU-1041, YD-8, and YD10B), compared with that of the cells transfected with the scrambled siRNA (Fig. 3b and c). Here, CBR1 is linked to head and neck squamous cell carcinoma.