MYC and neoplasm: Recent studies have highlighted a role for FAO in the growth of TNBC and suggested that targeting FAO may be beneficial to TNBC patients.10,13,14,59 The activation of FAO in TNBC has been linked to overexpression of the oncogene MYC, and previous studies have shown that inhibition of MYC increases lipid droplet formation in tumours by causing mitochondrial dysfunction.10,60,61 However, the mechanistic underpinnings by which MYC stimulates FAO in TNBC have remained elusive.