PDGFRB is a receptor tyrosine kinase (RTK) that induces intracellular Ca2+ release and has strong links to epithelial-to-mesenchymal transition (EMT), cell migration, and cancer progression.40,41 To assess the role of PDGFRB in the activation of FAO, we loaded MYC and TERT HME cells with the Ca2+-binding dye Fluo-3 and measured intracellular Ca2+ release in response to “puffing” its ligand, PDGF-BB, onto the cells (as previously described in ref. 42). The gene discussed is PDGFRB; the disease is cancer.