Multiple studies have suggested that mitochondria-localised carnitine acyltransferases, such as CPT1A and CPT2, are important regulators of FAO in breast cancer and critical for breast cancer growth.10,35,36 MYC and T58A HME cells had ~2-fold increases in CPT mRNA expression compared to TERT and HER2 (Supplementary Fig. S2d, e). This evidence concerns the gene MYC and breast carcinoma.