The exact mechanism by which MYC creates this conducive cellular state remains unknown, but may involve long-term dysregulation of Ca2+ signaling,62 alterations in microRNA expression,84 or epigenetic reprogramming.85 Amplification of Ca2+ signalling through downregulation of Ca2+ transporters has been noted as a potential tumour promoting mechanism in other cancer types, including the Eμ-myc model of lymphoma.62,63. This evidence concerns the gene MYC and cancer.