TWIST1 and neoplasm: Mesenchymal stem-like tumours have a high degree of dedifferentiation, low expression of claudins, loss of E-cadherin and CD24, and high expression of genes associated with EMT, including PDGFRB and TWIST.57 Furthermore, PDGFR signalling is known to induce EMT in breast cancer.58 Altogether, the major transcriptional changes that occurred in MYC HME cells are also the same changes that occur in CL-TNBC.