Besides MYC itself, we find upregulation of other breast cancer stem cell factors (SOX2, SOX18, THY1, EYA1, GLI2, SALL1, GLIS1, CXCR4), suggesting that MYC HME cells adopt a stem-like state (Supplementary Fig. S6i–l and Supplementary Table S1). The gene discussed is SOX2; the disease is breast cancer.