LRRC8A and agammaglobulinemia: Interestingly, LRRC8A was first found in a human patient with congenital agammaglobulinemia due to the lack of peripheral B cells (Sawada et al., 2003), whereas a later study in mice also indicates that the LRRC8A participates in the homeostasis of lymphocytes (Kumar et al., 2014).