HSPA8 and Parkinson disease: Detection of mutations in auxilin that increase such susceptibility is especially notable because, unlike Hsc70 or other chaperones that have multiple cellular functions, auxilin’s role appears to be limited to the single function of recruiting Hsc70 to CCVs to drive uncoating, so these observations strongly indicate that disruption of clathrin uncoating is a strong contributor to PD disease etiology.