In Akira Suzuki group’s study, MOB1a/1b double-mutant mice resulted in tumor development and upregulation of MOB1 inhibited several types of cancer development and progression, including osteosarcoma, hepatocellular carcinoma (HCC) and glioblastoma et al. [3, 6, 18]. Here, MOB1A is linked to hepatocellular carcinoma.