CHD4 and coronary artery disorder: Two DNVs in CHD4 (p.Y1345D and p.M202I), p.R1330W in IQGAP1, and p.S39F in ROCK2 were previously associated with CHD and p.M954I in CHD4 was associated with developmental disorder [2, 3, 9] (Additional file 8: Table S39).