In recent studies of CHD trios enrolled in the Pediatric Cardiac Genetics Consortium (PCGC) [8], significant enrichment for genes related to histone modification, chromatin modification, transcriptional regulation, neural tube development, and cardiac development and enrichment in pathways including Wnt, Notch, Igf, HDAC, ErbB, and NF-κB signaling have been reported [1–3]. This evidence concerns the gene NFKB1 and coronary artery disorder.