Overall, our results indicate significant enrichment of signaling pathways including Notch, ErbB and NF-κB signaling pathways that recent studies have associated with CHD [2, 3], as well as opioid, neuregulin, gap junction, VEGF, and FAK signaling pathways that were previously associated with heart disease [51–57]. The gene discussed is NFKB1; the disease is coronary artery disorder.