HK2 and gallbladder cancer: Furthermore, lncRNA PVT1 was found to regulate hexokinase 2 (HK2) expression by competitively binding to endogenous miR-143 in gallbladder cancer (GBC) cells, suggesting an important role of the PVT1/miR-143/HK2 axis in cell proliferation and metastasis by modulating aerobic glucose metabolism in GBC cells [15].