The results showed that the epithelial biomarker of E-cadherin, and GSK-3β, a key regulator of in Wnt/β-catenin signal pathway, were upregulated; whereas the mesenchymal biomarkers of N-cadherin and Vimentin, as well as Twist1 as an inducer of EMT, and β-catenin were downregulated in lung cancer cells with JPX knockdown (Fig. 8a). The gene discussed is TWIST1; the disease is lung cancer.