MBL2 and infectious disease: In addition, 3 substitutions including 2 in the promoter region of MBL2 (-550C/G or rs11003125 and -221G/C or rs7096206) and one in the UTR within the exon 1 (c.4T/C or rs7095891) have been shown to affect the level of MBL protein and influence the outcome of infectious diseases [9, 10].