ITGA5 and thanatophoric dysplasia: DEGs (TBXA2R, IL1R1, RPL17, ITGB3, ITGAV, ITGB2, RAC2, ITGA2, IQGAP2, GIT1, VAV1, ITGA5, RAP1B, FYN, PTPN11, PTCH1, NCOR2, MAML3) of potential pathways (Neuroactive ligand receptor interaction, MAPKs, ribosomes, regulation of actin cytoskeleton, focal adhesion, natural killer cell mediated cytotoxicity and the Notch signaling pathway) have important role in angiogenesis concerned to thiram induced TD chickens, most importantly integrin family, ribosome pathway and RPL17 gene.