In view of these shortcomings with acid-based stripping of IgE, we believe that this method could not be used for deciphering the functions of anti-IgE autoantibodies that are found in the healthy individuals and in several pathologies including atopic and non-atopic asthma, chronic spontaneous urticaria, atopic dermatitis and others [13,14,15,18,44,45,46,47,48,49,50]. This evidence concerns the gene IGHE and atopic eczema.