Dysregulated functions of basophils are associated with several atopic (characterized by high allergen-specific IgE) and non-atopic allergic (non IgE-mediated) diseases of skin, respiratory system and gastrointestinal tract (allergic rhinitis, atopic dermatitis, IgE-mediated chronic allergic inflammation) and autoimmune/inflammatory pathologies (bullous pemphigoid, eosinophilic oesophagitis, lupus nephritis, allograft rejection) [1,2,3,4,5,6,7,8]. Here, IGHE is linked to allergic rhinitis.