To determine whether the inhibitory activity of LicA on TrkB and BDNF expression in hypoxia is specific to the SK-N-SH cell line or if it is also exerted in cell lines from other neuroblastoma and/or tumors, we tested the effects of LicA on the amounts of TrkB and BDNF mRNA in the cell lines listed in Table 1. This evidence concerns the gene NTRK2 and neuroblastoma.