NR4A1 and hepatocellular carcinoma: On the basis of our previous finding that intrinsic CYP epoxygenase upregulation and elevation of EET metabolites are more pronounced in mesenchymal-like TNBC cells (e.g., MDA-MB-231) as compared with immortalized mammary epithelial cells (MCF10A), basal-like TNBC (e.g., MDA-MB-468 and HCC 1937) or hormone receptor positive (e.g., MCF7 and SKBR3) cell lines [25], in this study, we focused on assessing the functional roles of this signaling axis in the metastatic transformation of MDA-MB-231 TNBC cell line and its highly metastatic lung-seeking subclone.