Tumor nodules with positive Ki-67 staining were detected in the lungs of 231-iR2L (36% positive and 49% weak positive/negative), LM6-shLacZ (48% positive), and LM6-shFABP5 (37% positive and 44% weak positive/negative) groups, and little or marginal expression was found in shFABP4 (83% weak positive/negative) and shCYP2C19 (81% weak positive/negative) groups. The gene discussed is MKI67; the disease is neoplasm.