Although further mechanistic studies are needed to understand the dynamics of FABP4 and FABP5 acquisition and transcriptional activity in TNBC cells, or the influence of paracrine factors from stromal or other cells present in the local tumor or metastasis sites, for example, cytokines, adipokines, or endogenous lipophilic ligands, our work sheds light on the potential of targeting FABP4 and FABP5 activities in suppressing TNBC progression and metastatic transformation. Here, FABP4 is linked to neoplasm.