These data suggest that adipocytes (3T3-L1 differentiated adipocytes) or monocytes (THP-1) in the tumor microenvironment promote migration and invasion in parental (231-iR2L) and lung-seeking (LM6) TNBC cells that are potentially through paracrine factors or compensation of the FABP4 or FABP5 functions. Here, FABP5 is linked to neoplasm.