AKT1 and female reproductive organ cancer: It was also found that Triphala decreased the expression of phospho-Akt, phospho-p44/42, and phospho-NF-κB p56 in these gynecological cancer cells, which indicated that MAPK/ERK, PI3K/Akt/mTOR, and NF-κB/p53 signaling pathways were the possible mechanism of Triphala-induced apoptosis [60].