Interestingly, the anorexigenic effects induced by bisphenol A in mice were followed by the concomitant reduction and stimulation of CB1 and cocaine and amphetamine-regulating transcript (CART) peptide gene expression, respectively; thus, further highlighting the importance of hypothalamic arcuate nucleus first order neurons as key targets of the anti-obesity effects of CB1-modulating compounds [32]. The gene discussed is CNR1; the disease is obesity due to melanocortin 4 receptor deficiency.