In accordance with these findings, we could show that combining CA.19-9 with serum exosomal miR-200b and miR-200c in total as well as EpCAM-positive serum exosomes improved the tumor marker’s diagnostic accuracy by 18%, yielding an AUC of 0.97, sensitivity of 92%, and specificity of 100%. Here, EPCAM is linked to neoplasm.