After weight loss is induced by BS, it is possible to observe an improvement in glucose uptake (higher HK activity) and de novo lipogenesis (represented by ACC and FAS protein and mRNA expression levels), at the same time that insulin sensitivity improves (homeostasis model assessment of insulin resistance (HOMA-IR) decreases as well as the number of patients medicated for T2D, at the same time that AKT levels increase). The gene discussed is AKT1; the disease is Insulin resistance.