MAPT and early-onset autosomal dominant Alzheimer disease: Neurodegenerative disorders are described by the accumulation of insoluble aggregates of misfolded proteins in the central nervous system (CNS) such as Parkinson’s disease (PD), which is known by the aggregation of α-synuclein protein [1] and Alzheimer’s disease (AD), which demonstrates intracellular tau and extracellular amyloid-β deposition and hyperphosphorylated tau aggregates, respectively [2,3].