These results suggest that enhanced expression of these stemness-related factors may, in the context of embryonal rhabdomyosarcoma, result in a partial loss of mesenchymal phenotype, as indicated here by the progressive downregulation of a prominent EMT inducer, SNAI1, and CDH2, which encodes N-cadherin. The gene discussed is SNAI1; the disease is embryonal rhabdomyosarcoma.