Increased HCC pathology in Nlrp12-/- mice was associated with higher expressions of the HCC marker Afp, inflammatory cytokines, and chemokines, including IL-6, TNFα, Cxcl1, Cxcl2, and Ccl2, protooncogene cJun, cMyc, and Cyclin D1, and reduced expression of p21 [28]. The gene discussed is CCND1; the disease is hepatocellular carcinoma.