In caspase-1-deficient mice, tumorigenesis was increased in the Azoxymethane–Dextran sodium sulfate (AOM–DSS)-induced, colitis-associated colon cancer model, and the colonic epithelial cell proliferation in the early stage of tumorigenesis, and tumor cell proliferation was found [50]. This evidence concerns the gene CASP1 and malignant colon neoplasm.