Recently, we measured 33 circulating cytokines/chemokines in plasma of PyMT+ mice by using the Milliplex kit and reported that Tnf-α, Tgf-α, β, G-csf, Il-6, and Gm-csf are elevated, whereas Mip-2 Cxcl-2, Il-9, Cxcl-5, and Il-1α are decreased in tumor-bearing mice compared to age and sex-matched control animals [13]. This evidence concerns the gene IL6 and neoplasm.