Based on the discovery of familial Alzheimer’s Disease (FAD) mutated genes, transgenic AD models consisted of APP23 mice, APPswe/PS1dE9 mice, 3×Tg-AD mice (PS1M146V knock-in, APPswe, taup301L), and 5×FAD mice (APP695 harboring Swedish, Florida, London mutations, and PS1 harboring M146L, L286V mutations) have been extensively developed. This evidence concerns the gene PSEN1 and familial Alzheimer disease.