Besides, Khan A. et al. [13] also indicated that quercetin halted the activated TLR4/NFKB pathway which is responsible for inflammatory signaling, and tempered the expressions of several inflammatory mediators, such as TNF-α, COX-2, NOS-2, and IL-1β in AD mice’s cortexes and hippocampi. Here, IL1B is linked to Alzheimer disease.