TP53 and diffuse intrinsic pontine glioma: Strikingly, DIPG patients with TP53 mutations were found to have a worse clinical and radiological response to radiation treatment compared to DIPG patients with wild-type TP53. TP53 mutant patients also showed a shorter time to relapse after radiation treatment compared to the patients with wild-type TP53, and a worse overall prognosis [24].