However, in the 50 mg/kg and 100 mg/kg LA/ischemia group, hypertrophy (activation) of Iba-1 immunoreactive microglia was markedly reduced compared to that in the vehicle/ischemia group (Figure 5B,D,F,H), and the ROD in each group was 114% and 115%, respectively, of the vehicle/sham group (Figure 5I). Here, AIF1 is linked to ischemia.