Thus, our observations on the potent suppression of both AR-FL and AR-V7 by the low-dose CDDO-Me implicate its potential to be used in both the early stage PC where the cancer cells are hormone dependent, as well as in the late stage of CRPC tumors where the cancer cells have selected for an androgen independent phenotype, but are still expressing AR-FL and AR-V7. The gene discussed is AR; the disease is pachyonychia congenita.