FOXO3 and diabetic kidney disease: On one hand, H2O2 would mimic a prooxidant environment that can be reached in the respiratory tract by bacterial or viral infections [26,27], and on the other hand, the deregulation of AKT/FoxO3a signaling has a central role during cellular disturbances found in diseases such as leukemia [28], diabetic kidney disease [29], and breast cancer [30], among others.