Although the effects of MMP11 rs131451 and the correlations between aging and MMP11 SNPs remained limited, it was suggested that lower expression of MMP11 was associated with better overall survival of bladder cancer patients [42], suggesting that the MMP11 rs131451 “CC” variants might be associated with lower level of MMP11 expression and protective effect among UCC patients whose age ≤65 years (Table 4). Here, MMP11 is linked to urinary bladder carcinoma.