Intriguingly, among these MMP11 SNPs selected in our study, although the MMP11 rs131451 polymorphisms “CC” genotype were not associated with the clinical status in 431 UCC patients involved in our study (Table 3), we found that the MMP11 rs131451 “CC” polymorphic variants were associated with lower risk to develop later tumor T status compared with the “CT + TT” genotype in 166 UCC patients among age ≤ 65 years old (p = 0.026, OR: 0.375, 95% CI: 0.159–0.887; Table 4). Here, MMP11 is linked to neoplasm.