Deletion and inhibition of NLRP3 or caspase-1 mitigates dopaminergic neuronal loss in mouse models of PD created by injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or 6-hydroxydopamine or transgenic overexpression of α-synuclein [15,16,44,45,46]. Here, CASP1 is linked to Parkinson disease.