Reexpression of p53 in tumors can induce their ability to produce various inflammatory cytokines (Iannello et al., 2013), prompting us to examine whether conditioned media from the KC- and KFC-tumor derived cells could impact macrophage surface activation markers: major histocompatibility complex (MHC) class I, MHC class II, PD-L1, and CD80. This evidence concerns the gene TP53 and neoplasm.