Loss of PTEN, another common oncogenic event, results in resistance to PD-1 blockade in both melanoma and uterine leiomyosarcoma (George et al., 2017, Peng et al., 2016), while β-catenin signaling in melanoma was shown to limit T cell infiltration (Spranger et al., 2015). The gene discussed is PTEN; the disease is melanoma.