Numerous studies have shown a role for macrophages in supporting cancer progression (Cassetta and Pollard, 2018, Noy and Pollard, 2014, Prenen and Mazzone, 2019, Qian and Pollard, 2010), and so we examined whether loss of p53 in autochthonous mouse models of pancreatic and lung cancers could influence myeloid cell recruitment to the tumor microenvironment (TME). This evidence concerns the gene TP53 and lung cancer.