Induction of apoptosis through the interaction of TRAIL with its receptors on the surface of cancer cells is a well-described mechanism of tumor surveillance [19], and the in vivo importance of loss of sensitivity to TRAIL-mediated apoptosis has been demonstrated by multiple clinical studies showing a correlation between TRAIL receptor expression, poor prognosis, and tumor recurrence [20]. The gene discussed is TNFSF10; the disease is neoplasm.