The significance of our findings might reach well beyond allergy, especially since mast cells also participate in a variety of inflammatory settings that involve neutrophilic inflammation (e.g., tumorigenesis [54], autoimmunity [55], infection [56, 57]) and IL-33 is likely involved in several other inflammatory diseases (e.g., rheumatoid arthritis [19], ankylosing spondylitis [20], psoriasis [23], cystic fibrosis [58], antiviral Th1-mediated immunity [59]). The gene discussed is IL33; the disease is cystic fibrosis.