Overexpression of p21 (Fig 6D and 6E) did not alter the levels of FXR1 (Fig 6D and 6E) or miR301a-3p (Fig 6F) in the oral cancer cells tested here, suggesting that consumption of miR301a-3p or feedback regulation of p21-mediated control of either miR301a or FXR1 was not occurring in the oral cancer cells. Here, CDKN1A is linked to lip and oral cavity carcinoma.