To further confirm the cell line results, we used UCSC XENA and found up-regulated FXR1 (p = 0.0139) and PNPT1 (p = 0.00017) in primary tumors, compared to normal solid tissue (604 total HNSCC patients’ samples) by one-way ANOVA (S4A Fig). Here, PNPT1 is linked to head and neck squamous cell carcinoma.