TG and infection: Ligands signaling different aspects of challenge (termed here group A: stress, infection, inflammation, blood pressure fall) were principally found to target receptors expressed in DG, whereas ligands signaling aspects of sufficiency (group B: androgens, endocrine FGF, estrogens, progestins, retinoic acid, thyroid hormones) instead principally target the CA regions, with a mean 8.33-fold difference in the DG versus CA expression ratio (P < 0.0001).