POLR3A and movement disorder: It also differs from a subform of spastic ataxia and the rare Wiedemann-Rautenstrauch syndrome (OMIM#264090), which have only recently been associated with POLR3A. Clinical presentation of these nine patients forms a continuum between a severe, extrapyramidal movement disorder with early onset at one end and juvenile parkinsonism with onset in childhood at the other end of the spectrum.