This study therefore aimed to investigate the performance of each biomarker (MR-proADM, PCT, CRP and lactate) and clinical score (SOFA and APACHE II) in patients fulfilling the criteria for the Vall d’Hebron University in-hospital sepsis code (ISC) in order to: (1) discriminate between infected and non-infected patients; (2) assess infection severity according to 28- and 90-day mortality prediction, and (3) identify patients presenting to the ED or undergoing treatment on a medical/surgical ward who require subsequent ICU admission. Here, CRP is linked to Sepsis.