Compared with men with a baseline PSA level between 1.00 and 1.99 ng/mL, the 13-year risk of clinically significant PCa nearly doubled for men with a baseline PSA level between 2.00 and 2.99 ng/mL (10.6%; 95% CI, 8.3%-12.9%). This evidence concerns the gene KLK3 and posterior cortical atrophy.