We found that the 13-year incidence of clinically significant PCa diagnosis (as defined by those with metastatic potential,22,23 ie, clinical or pathologic Gleason grade, ≥7; clinical stage, ≥cT2b; pathologic stage, ≥pT3; pathologic node-positive disease; or death from PCa) among men aged 55 to 60 years with PSA levels less than 2.00 ng/mL ranged from 0% to 5%, while the 13-year risk among similarly aged men with PSA levels of 2.00 ng/mL or greater ranged from 11% to 30%. This evidence concerns the gene KLK3 and posterior cortical atrophy.