Specifically, younger men (ie, aged 55-60 years) with a baseline PSA level between 0.50 and 0.99 ng/mL had an estimated 1.5% (95% CI, 1.1%-1.9%) long-term incidence of clinically significant PCa, and for men with a baseline PSA level between 1.00 and 1.99 ng/mL, the actuarial rate was 5.4% (95% CI, 4.4%-6.4%). Here, KLK3 is linked to posterior cortical atrophy.