DOT1L and metastatic malignant neoplasm in the lymph nodes: DOT1L expression correlated with differentiation degree (P=0.04), lymph node metastasis (P<0.01) and TNM stage (P<0.01), but had no significant relationship with age (P=0.727), gender (P=0.188), tumor size (P=0.165), tumor location (P=0.452), depth of invasion (P=0.065), invading vessel (P=0.924) and invading nerve (P=0.748) (Table 1).