This might be of particular importance in patients with newly diagnosed or not successfully operated patients with uncontrolled acromegaly and GH concentrations > 10 μg/L: As mentioned above, in that range of high GH concentrations, IGF-I has been shown to exhibit a ceiling effect, making it less reliable as a biomarker for dose titration of any administered drug. The gene discussed is IGF1; the disease is acromegaly.