GH1 and hypopituitarism: Interestingly, evaluation of IS by the EHC method in patients with GHD showed that patients with onset of GHD in early life had better IS when compared with controls paired by sex, age, and BMI, while patients with hypopituitarism who started hormone deficiency later in life have IS similar to the control group, suggesting that adipose tissue that did not undergo the physiological action of GH during early childhood should be different from adipose tissue that experienced this action at this stage of life, since the former is more sensitive to insulin action, results not yet published (99).