NFATC2 and AIDS: As experience accumulated from patients enrolled in the NFATP, it was observed that lipodystrophy—the major side effect of d4T—usually manifested after 6 months of treatment, whereas bone marrow suppression from AZT exposure occurred soon after ART initiation, partially due to the fact that most Chinese HIV/AIDS patients were diagnosed at a relatively late stage and initiated on treatment when they were more susceptible to bone marrow suppression.