It has also been reported by others as a pathogenic sequence variant of the MMR genes causing Lynch syndrome [30], and can be found in multiple databases, such as ClinVar, dbSNP, and OMIM databases (https://www.ncbi.nlm.nih.gov/clinvar/variation/89739, https://www.ncbi.nlm.nih.gov/snp/587778914). Based on these circumstances, we suspect that this is a European founder mutation. Here, MRC1 is linked to Lynch syndrome.