Hereditary nonpolyposis colorectal carcinoma (Lynch syndrome), also known as Lynch syndrome, is a highly penetrant, autosomal dominant disease involving a mutation in one of the four DNA mismatch repair (MMR) genes (MLH1, MSH2, MSH6, or PMS2) or EPCAM. It is the most common cause of inherited colorectal cancer (CRC), accounting for approximately 3–6% of all cases [1, 2]. This evidence concerns the gene PMS2 and Lynch syndrome.