To characterize how the SNAI2/PRC2/HDAC1 complex and STAT3 functioned together in pri-miR-204 promoter at both of SNAI2 and STAT3 binding sites, ChIP experiments were further performed for SUZ12, SNAI2, STAT3, HDAC1 and H3K37me3 using crosslinked chromatin from HNSCC cells treated with SNAI2 and STAT3 siRNAs. Here, SUZ12 is linked to head and neck squamous cell carcinoma.