However, miRNAs are well-known to regulate multiple target genes at post-transcription level and some miR-204-5p target genes have been identified in HNSCC, including IGFBP5 40, CXCR4 41, FOXC1 42, SNAI2 and SOX4 43. This evidence concerns the gene IGFBP5 and head and neck squamous cell carcinoma.