On the other hand, the miR-204-5p associated DEGs were involved in Rac signaling, colorectal cancer metastasis signaling and TGFβ signaling (Figure S3A), a well-known regulator of epithelia-mesenchymal transition (EMT), supporting the observations that miR-204-5p inhibited invasion and metastasis. This evidence concerns the gene AKT1 and colorectal cancer.