Consistently, staining of xenograft sections with IHC showed that expression of SUZ12, SNAI2, HDAC1, JAK2 and p-STAT3 was decreased but E-cadherin expression was increased in agomiR-204-5p-treated mice as compared to those in the control group (Figure 7Q), confirming that the administration of miR-204-5p could suppress tumor progression by targeting SUZ12, SNAI2, JAK2 and HDAC1 in vivo. This evidence concerns the gene STAT3 and neoplasm.