Multiple receptors including Integrin receptors 129, Transferrin Receptors (TfR)130, Epidermal Growth Factor Receptors (EGFR)131, Folate Receptors (FR)132 and Glycyrrhetinic Acid (GA) Receptors133 have been used as specific molecules for active targeting to kill tumor cells. The gene discussed is TFRC; the disease is neoplasm.