Second, we have demonstrated that SIRT1 inhibits vascular inflammation via suppressing the activation of NF-κB and the expression of pro-inflammatory factors in VSMCs 24, 43, and however, whether SIRT1 inhibiting NF-κB signaling limits accumulation of monocytes/macrophages due to decreased expression of adhesion molecules further leading to decrease in local level of VEGFA, a crucial pathological process involved in angiogenesis after ischemia, thereby impairing angiogenesis after ischemia, also remains unknown. This evidence concerns the gene NFKB1 and ischemia.