As the enhanced therapeutic efficacy, minimal toxicity, targeting ability and cell permeability 22, 23, arginine-based PTP (Plectin-1-targeting peptide)-displayed chimeric peptide-condensed supramolecular nanoparticles were employed for delivering small RNAs specifically to plectin-1-targeted pancreatic cancer cells 21. Here, PLEC is linked to familial pancreatic carcinoma.