The mechanism of the downregulation may associate with DNA hypermethylation of its promoter and copy number loss 28, 45, histone deacetylation due to the deregulation of HDACs 33 or the post-transcriptional modification mediated by MAGE-TRIM28 leading to the degradation of FBP1 in cancer cells 46. The gene discussed is FBP1; the disease is cancer.