Indeed, PTPN13 inhibits vascular endothelial cell movement through interaction with NECL-4 and VEGFR 47, reduces the invasive capacity of PC3 prostate cancer cells 48, negatively regulates the growth of NCI-H292 lung cancer cells in vitro and in vivo20, and inhibits invasion by HEPG2 and 97H hepatocellular carcinoma cell lines 24. This evidence concerns the gene CADM4 and prostate cancer.